Research Article

The Correlation between FSTL1 Expression and Airway Remodeling in Asthmatics

Table 1

Patient characteristics.

ControlsAsthmatics value

n2532
Age (years)40.84 ± 18.66542.31 ± 15.4220.746a
Gender, male (%)10 (40.000)11 (34.375)0.662b
BMI (kg/m2)24.748 ± 2.97625.500 ± 4.5370.477a
WBC# (×109/L)6.251 ± 2.0087.460 ± 2.7870.092a
neu# (×109/L)3.935 ± 1.9984.609 ± 2.8290.348a
eos# (×109/L)0.100 ± 0.1050.473 ± 0.7060.006c
neu%61.148 ± 14.60858.813 ± 15.9270.592a
eos%1.652 ± 1.6875.938 ± 8.3780.008c
log10 (FSTL1)1.945 ± 0.1942.091 ± 0.1520.002a
FSTL1 (ng/mL)95.408 ± 33.938130.762 ± 46.0290.009d
FEV1 (%predicted)99.245 ± 10.23677.502 ± 16.989<0.001c
FEV1/FVC84.787 ± 3.08770.261 ± 10.521<0.001c
Zrs (Ω)104.252 ± 27.344271.991 ± 91.064<0.001c
Fres (1/s)11.436 ± 2.75425.313 ± 7.088<0.001c
R5 (cmH2O/(L/s))101.052 ± 27.009216.334 ± 67.657<0.001c
R20 (cmH2O/(L/s))96.620 ± 27.588157.634 ± 24.796<0.001a
R5-R20 (cmH2O/(L/s))10.208 ± 7.35163.944 ± 60.949<0.001c
X5 (cmH2O/(L/s))0.599 ± 0.4514.190 ± 2.570<0.001c

Data are presented as mean ± SD; the values of WBC#, neu#, eos#, neu%, and eos% were in blood. The values of FSTL1 were in plasma; BMI: body mass index; WBC#: white blood cell count; neu#: neutrophil count; eos#: eosinophil count; neu%: neutrophil percentage; eos%: eosinophil percentage; FEV1: forced expiratory volume in one second; FEV1/FVC: forced expiratory volume in one second/forced vital capacity; Zrs: respiratory system impedance; Fres: resonant frequency; R5: resistance at 5 Hz; R20: resistance at 20 Hz; X5: reactance at 5 Hz; R5-R20: R5 was subtracted by R20; atwo-tailed independent sample t-test; bPearson chi-square test; cseparate variance estimation t-test; dMann–Whitney U; .