The Correlation between FSTL1 Expression and Airway Remodeling in Asthmatics
Table 1
Patient characteristics.
Controls
Asthmatics
value
n
25
32
Age (years)
40.84 ± 18.665
42.31 ± 15.422
0.746a
Gender, male (%)
10 (40.000)
11 (34.375)
0.662b
BMI (kg/m2)
24.748 ± 2.976
25.500 ± 4.537
0.477a
WBC# (×109/L)
6.251 ± 2.008‡
7.460 ± 2.787
0.092a
neu# (×109/L)
3.935 ± 1.998‡
4.609 ± 2.829
0.348a
eos# (×109/L)
0.100 ± 0.105‡
0.473 ± 0.706
0.006c
neu%
61.148 ± 14.608‡
58.813 ± 15.927
0.592a
eos%
1.652 ± 1.687‡
5.938 ± 8.378
0.008c
log10 (FSTL1)
1.945 ± 0.194
2.091 ± 0.152
0.002a
FSTL1 (ng/mL)
95.408 ± 33.938
130.762 ± 46.029
0.009d
FEV1 (%predicted)
99.245 ± 10.236
77.502 ± 16.989
<0.001c
FEV1/FVC
84.787 ± 3.087
70.261 ± 10.521
<0.001c
Zrs (Ω)
104.252 ± 27.344
271.991 ± 91.064
<0.001c
Fres (1/s)
11.436 ± 2.754
25.313 ± 7.088
<0.001c
R5 (cmH2O/(L/s))
101.052 ± 27.009
216.334 ± 67.657
<0.001c
R20 (cmH2O/(L/s))
96.620 ± 27.588
157.634 ± 24.796
<0.001a
R5-R20 (cmH2O/(L/s))
10.208 ± 7.351
63.944 ± 60.949
<0.001c
X5 (cmH2O/(L/s))
0.599 ± 0.451
4.190 ± 2.570
<0.001c
Data are presented as mean ± SD; the values of WBC#, neu#, eos#, neu%, and eos% were in blood. The values of FSTL1 were in plasma; BMI: body mass index; WBC#: white blood cell count; neu#: neutrophil count; eos#: eosinophil count; neu%: neutrophil percentage; eos%: eosinophil percentage; FEV1: forced expiratory volume in one second; FEV1/FVC: forced expiratory volume in one second/forced vital capacity; Zrs: respiratory system impedance; Fres: resonant frequency; R5: resistance at 5 Hz; R20: resistance at 20 Hz; X5: reactance at 5 Hz; R5-R20: R5 was subtracted by R20; atwo-tailed independent sample t-test; bPearson chi-square test; cseparate variance estimation t-test; dMann–Whitney U; ‡.