Helminth Products Potently Modulate Experimental Autoimmune Encephalomyelitis by Downregulating Neuroinflammation and Promoting a Suppressive Microenvironment
TcES treatments alter lymphoid cell migration patterns. Leukocytes were obtained from the peritoneum, spleen, CLNs, CNS, and blood and were stained to detect CD4+ and CD8+ cells. Numbers (a) and relative frequencies of either CD4+ or CD8+ cells are shown (b). Cells were gated from a small and nongranular region to plot CD4+ & CD8+ cells. Cell numbers were calculated from a gate of 10000 total cells. The data shown are representative of 2 independent experiments. Means and SEM were calculated for a group of mice. The statistical significance between groups was determined by two-tailed Student’s t-test, and . No statistically significant differences were found in CD8+ cells.
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