Helminth Products Potently Modulate Experimental Autoimmune Encephalomyelitis by Downregulating Neuroinflammation and Promoting a Suppressive Microenvironment

Table 4

TcES withdrawal reduces treatment efficacy.

Treatment	Resolution (%)	Average grade	Maximum grade	CDI	Late CDI	AUC
EAE + BSA	0%	2 ± 1.1	3.5	97.5	71.5	29
EAE + TcES	0%	0.8 ± 0.4	1.5	39.5	21	12
EAE + TcES-W	0%	1.5 ± 0.7	2.5	67	47.5	19.9

Resolution = percentage of mice in which disease resolved completely; average grade = average grade of disease of each group; maximum grade = the peak clinical score for each group; late CDI = CDI calculated from treatment withdrawal (day 19) until sacrifice (day 26). CDI: cumulative disease index (calculated as the sum of all grades for each group); AUC: area under the curve. The data shown are representative of 2 independent experiments. Means and SEM were calculated for a group of mice. The statistical significance between groups was determined by two-way ANOVA test, and . All statistical comparisons were made against the groups pinpointed by the blue parenthesis.