Table of Contents Author Guidelines Submit a Manuscript
Mediators of Inflammation
Volume 2017, Article ID 8506072, 6 pages
https://doi.org/10.1155/2017/8506072
Research Article

Elevation of Platelet and Monocyte Activity Markers of Atherosclerosis in Haemodialysis Patients Compared to Peritoneal Dialysis Patients

11st Medical Department, University Medical Centre Mannheim, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany
25th Medical Department, University Medical Centre Mannheim, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany
3Herzzentrum Weinheim, University Medical Centre Mannheim, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany

Correspondence should be addressed to Anna-Isabelle Kälsch; ed.mmu@hcsleak.ellebasi-annA

Received 24 January 2017; Revised 29 May 2017; Accepted 11 June 2017; Published 9 July 2017

Academic Editor: Giuseppe Valacchi

Copyright © 2017 Ksenija Stach et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose. The predominant cause of mortality in dialysis patients are cardiovascular events. Platelet and monocyte activity markers play an important role in cardiovascular mortality and were assessed and related to dialysis quality criteria in haemodialysis (HD) and peritoneal dialysis (PD) patients. Methods. For this prospective comparative study, HD patients () and PD patients () were included. In whole blood samples, surface expression of CD62P and CD40L on platelets, tissue factor binding on monocytes, and platelet-monocyte aggregates were measured by flow cytometry. Plasma levels of MCP-1, IL-6, TNFα, and soluble CD40L were analysed by enzyme-linked immunosorbent assay. Results. Haemodialysis patients showed a significantly higher CD62P expression on platelets (), significantly higher amount of platelet-monocyte aggregates (), and significantly more tissue factor binding on monocytes () compared to PD patients. In PD patients, a significant correlation between Kt/V and platelet CD40L expression (; 0.001) and between Kt/V and platelet CD62P expression (; ) was observed, while there was no significant correlation between Kt/V and tissue factor binding on monocytes and platelet-monocyte aggregates, respectively. Conclusion. Platelet and monocyte activity markers are higher in HD patients in comparison with those in PD patients, possibly suggesting a higher risk of cardiovascular morbidity and mortality.