κ-Carrageenan Enhances Lipopolysaccharide-Induced Interleukin-8 Secretion by Stimulating the Bcl10-NF-κB Pathway in HT-29 Cells and Aggravates C. freundii-Induced Inflammation in Mice

Figure 1

κ-Carrageenan enhances LPS-induced IL-8 secretion in HT-29 cells. (a) The effect of LPS on time-course and dose-response in HT-29 cells. (b) κ-Carrageenan increased LPS-induced expression of IL-8. IL-8 expression was assessed by ELISA in HT-29 cells treated with or without different concentrations of LPS (0.01, 0.1, and 1 μg/mL) for 0.5 h, 1 h, 2 h, 4 h, 6 h, 12 h, and 24 h or treated with κ-carrageenan at the indicated doses in the absence or presence of 1 μg/mL LPS. , compared with the blank group. , compared with the LPS treated alone.

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