κ-Carrageenan Enhances Lipopolysaccharide-Induced Interleukin-8 Secretion by Stimulating the Bcl10-NF-κB Pathway in HT-29 Cells and Aggravates C. freundii-Induced Inflammation in Mice

Figure 2

κ-Carrageenan enhances LPS-induced TLR4 expression in HT-29 cells. (a) The effect of κ-carrageenan on the expression of TLR4 in HT-29 cells. (b) κ-Carrageenan increased LPS-induced expression of TLR4. Cells were treated with κ-carrageenan for 24 h or were pretreated with κ-carrageenan for 1 h and then with LPS (1 μg/mL) for 24 h. (c) TLR4 expression in HT-29 cells is affected by κ-carrageenan. Cells were treated with κ-carrageenan for 24 h and then were incubated with 1 μg PE-TLR4 for 25 min. , , compared with the blank group. , compared with those in the LPS alone treated group.compared with the LPS treated alone. (d) -axis shows the mean fluorescent intensity of PE-TLR4.

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