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Mediators of Inflammation
Volume 2017, Article ID 8670280, 6 pages
Review Article

Effector and Regulatory T Cell Trafficking in Corneal Allograft Rejection

1Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, Boston, MA, USA
2Department of Ophthalmology, Harvard Medical School, Boston, MA, USA

Correspondence should be addressed to Sunil K. Chauhan; ude.dravrah.ieem@nahuahc_linus

Received 24 January 2017; Accepted 26 March 2017; Published 30 April 2017

Academic Editor: Paul Proost

Copyright © 2017 Afsaneh Amouzegar and Sunil K. Chauhan. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Corneal transplantation is among the most prevalent and successful forms of solid tissue transplantation in humans. Failure of corneal allograft is mainly due to immune-mediated destruction of the graft, a complex and highly coordinated process that involves elaborate interactions between cells of innate and adaptive immunity. The migration of immune cells to regional lymphoid tissues and to the site of graft plays a central role in the immunopathogenesis of graft rejection. Intricate interactions between adhesion molecules and their counter receptors on immune cells in conjunction with tissue-specific chemokines guide the trafficking of these cells to the draining lymph nodes and ultimately to the site of graft. In this review, we discuss the cascade of chemokines and adhesion molecules that mediate the trafficking of effector and regulatory T cells during corneal allograft rejection.