The Role of Intestinal Alkaline Phosphatase in Inflammatory Disorders of Gastrointestinal Tract

Table 1

Characteristics of animal studies examining potential role of IAP in experimental colitis.

Reference	Study type	Study outcome
Goldberg et al., 2008 [21]	IAP-knockout mice (C57BL/6 background)	In mice with intestinal barrier dysfunction induced by ischemia the IAP-knockout mice had increased severity of intestinal inflammation and increased bacterial translocation as compared to wild-type mice.
Martínez-Moya et al. 2012 [6]	Wistar rats	IAP was given to rats by the oral or intrarectal route and have beneficial effects on experimental trinitrobenzene sulfonic acid (TNBS) and dextran sulfate sodium (DSS) model of rat colitis, which includes protection against bacterial translocation. Treatment with intrarectal IAP was more effective than oral route.
Tuin et al., 2009 [19]	Sprague-Dawley; Rats	Orally administered IAP caused a significant reduction of inflammation in rat model of DSS -induced colitis in rats.
Bol-Schoenmakers et al., 2010 [25]	C57BL/6J mice	In DSS induced colitis, the oral IAP administration exerts a beneficial effect against severe intestinal epithelial damage. Rectal administration of LPS into a moderate inflamed colon did not aggravate inflammation.
Ramasamy et al., 2011 [26]	IAP-KO and; WT C57BL/6 mice; WASP-KO (129 SvEv background) mice	In two independent mouse models of chronic colitis: DSS-induced mouse colitis model in wild type mice and IAP knock out mice and the irradiation induced WASP-KO colitis, orally administered IAP significantly attenuated inflammation in both, IAP-knockout and wild-type mice in the chronic colitis model.
Lee et al., 2014 [27]	IL-10−/− mice (C57BL/6 background)	In piroxicam-induced IL-10 knockout mice, the significant reduction of experimental colitis severity was observed after oral administration of IAP.