Table of Contents Author Guidelines Submit a Manuscript
Mediators of Inflammation
Volume 2017, Article ID 9401432, 9 pages
https://doi.org/10.1155/2017/9401432
Research Article

Serum Interleukin-23 in Polish Patients with Systemic Lupus Erythematosus: Association with Lupus Nephritis, Obesity, and Peripheral Vascular Disease

1Independent Laboratory for Rheumatologic Diagnostics, Pomeranian Medical University in Szczecin, Unii Lubelskiej 1, 71-252 Szczecin, Poland
2Department of Rheumatology, Internal Medicine and Geriatrics, Pomeranian Medical University in Szczecin, Unii Lubelskiej 1, 71-252 Szczecin, Poland
3Department of Imaging Diagnostics and Interventional Radiology, Pomeranian Medical University in Szczecin, Unii Lubelskiej 1, 71-252 Szczecin, Poland

Correspondence should be addressed to Katarzyna Fischer; moc.liamg@11rehcsif.anyzratak

Received 23 June 2017; Revised 7 November 2017; Accepted 27 November 2017; Published 21 December 2017

Academic Editor: Rosa E. Navarro-Hernandez

Copyright © 2017 Katarzyna Fischer et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. C. Bombardier, D. D. Gladman, M. B. Urowitz et al., “Derivation of the SLEDAI. A disease activity index for lupus patients,” Arthritis & Rheumatism, vol. 35, no. 6, pp. 630–640, 1992. View at Publisher · View at Google Scholar · View at Scopus
  2. M. Molokhia and P. McKeigue, “Systemic lupus erythematosus: genes versus environment in high risk populations,” Lupus, vol. 15, no. 11, pp. 827–832, 2006. View at Publisher · View at Google Scholar · View at Scopus
  3. L. A. Criswell, “The genetic contribution to systemic lupus erythematosus,” Bulletin of the NYU Hospital for Joint Diseases, vol. 66, no. 3, pp. 176–183, 2008. View at Google Scholar
  4. Y. Shoenfeld, D. Alarcon-Segovia, D. Buskila et al., “Frontiers of SLE: review of the 5th International Congress of Systemic Lupus Erythematosus, Cancun, Mexico, April 20–25, 1998,” Seminars in Arthritis & Rheumatism, vol. 29, no. 2, pp. 112–130, 1999. View at Publisher · View at Google Scholar · View at Scopus
  5. L. E. Muñoz, K. Lauber, M. Schiller, A. A. Manfredi, and M. Herrmann, “The role of defective clearance of apoptotic cells in systemic autoimmunity,” Nature Reviews Rheumatology, vol. 6, no. 5, pp. 280–289, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. D. Yan Hin Yap and K. Neng Lai, “Cytokines and their roles in the pathogenesis of systemic lupus erythematosus: from basics to recent advances,” Journal of Biomedicine and Biotechnology, vol. 2010, Article ID 365083, 10 pages, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. B. Oppmann, R. Lesley, B. Blom et al., “Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12,” Immunity, vol. 13, no. 5, pp. 715–725, 2000. View at Publisher · View at Google Scholar
  8. C. Parham, M. Chirica, J. Timans et al., “A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rβ1 and a novel cytokine receptor subunit, IL-23R,” The Journal of Immunology, vol. 168, no. 11, pp. 5699–5708, 2002. View at Publisher · View at Google Scholar
  9. E. Duvallet, L. Semerano, E. Assier, G. Falgarone, and M. C. Boissier, “Interleukin-23: a key cytokine in inflammatory diseases,” Annals of Medicine, vol. 43, no. 7, pp. 503–511, 2011. View at Publisher · View at Google Scholar · View at Scopus
  10. Y. Iwakura and H. Ishigame, “The IL-23/IL-17 axis in inflammation,” The Journal of Clinical Investigation, vol. 116, no. 5, pp. 1218–1222, 2006. View at Publisher · View at Google Scholar · View at Scopus
  11. K. Komura, M. Fujimoto, M. Hasegawa et al., “Increased serum interleukin 23 in patients with systemic sclerosis,” The Journal of Rheumatology, vol. 35, no. 1, pp. 120–125, 2008. View at Google Scholar
  12. R. M. Talaat, S. F. Mohamed, I. H. Bassyouni, and A. A. Raouf, “Th1/Th2/Th17/Treg cytokine imbalance in systemic lupus erythematosus (SLE) patients: correlation with disease activity,” Cytokine, vol. 72, no. 2, pp. 146–153, 2015. View at Publisher · View at Google Scholar · View at Scopus
  13. D. Popovic-Kuzmanovic, I. Novakovic, L. Stojanovich et al., “Increased activity of interleukin-23/interleukin-17 cytokine axis in primary antiphospholipid syndrome,” Immunobiology, vol. 218, no. 2, pp. 186–191, 2013. View at Publisher · View at Google Scholar · View at Scopus
  14. H. Przepiera-Będzak, K. Fischer, and M. Brzosko, “Serum IL-6 and IL-23 levels and their correlation with angiogenic cytokines and disease activity in ankylosing spondylitis, psoriatic arthritis, and SAPHO syndrome,” Mediators of Inflammation, vol. 2015, Article ID 785705, 7 pages, 2015. View at Publisher · View at Google Scholar · View at Scopus
  15. H. Przepiera-Będzak, K. Fischer, and M. Brzosko, “Extra-articular symptoms in constellation with selected serum cytokines and disease activity in spondyloarthritis,” Mediators of Inflammation, vol. 2016, Article ID 7617954, 7 pages, 2016. View at Publisher · View at Google Scholar
  16. M. Mohammadi, M. M. Hayatbakhsh, M. J. Zahedi, M. R. Jalalpour, and A. Pakgohar, “Serum interleukin-23 levels in patients with ulcerative colitis,” Iranian Journal of Immunology, vol. 8, no. 3, pp. 183–188, 2011. View at Google Scholar
  17. C. K. Wong, L. C. W. Lit, L. S. Tam, E. K. M. Li, P. T. Y. Wong, and C. W. K. Lam, “Hyperproduction of IL-23 and IL-17 in patients with systemic lupus erythematosus: implications for Th17-mediated inflammation in auto-immunity,” Clinical Immunology, vol. 127, no. 3, pp. 385–393, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. D. Salah Hegab, M. Mahmoud Gamei, W. Mohamed Saudi, D. Ezzat Abou Ammo, M. Mohamed El Bedewy, and N. Fathy Elhabian, “Role of interleukin-23 in the immunopathogenesis of systemic lupus erythematosus,” Egyptian Journal of Dermatology and Venerology, vol. 34, no. 2, pp. 120–125, 2014. View at Publisher · View at Google Scholar
  19. M. Yin Mok, H. Jing Wu, Y. Lo, and C. Sing Lau, “The relation of interleukin 17 (IL-17) and IL-23 to Th1/Th2 cytokines and disease activity in systemic lupus erythematosus,” The Journal of Rheumatology, vol. 37, no. 10, pp. 2046–2052, 2010. View at Publisher · View at Google Scholar · View at Scopus
  20. J. Du, Z. Li, J. Shi, and L. Bi, “Associations between serum interleukin-23 levels and clinical characteristics in patients with systemic lupus erythematosus,” Journal of International Medical Research, vol. 42, no. 5, pp. 1123–1130, 2014. View at Publisher · View at Google Scholar · View at Scopus
  21. A. Abbas, I. Gregersen, S. Holm et al., “Interleukin 23 levels are increased in carotid atherosclerosis. Possible role for interleukin 23/interleukin 17 axis,” Stroke, vol. 46, no. 3, pp. 793–799, 2015. View at Publisher · View at Google Scholar · View at Scopus
  22. A. David, S. Saitta, G. De Caridi et al., “Interleukin-23 serum levels in patients affected by peripheral arterial disease,” Clinical Biochemistry, vol. 45, no. 3, pp. 275–278, 2012. View at Publisher · View at Google Scholar · View at Scopus
  23. M. Sumarac-Dumanovic, D. Stevanovic, A. Ljubic et al., “Increased activity of interleukin-23/interleukin-17 proinflammatory axis in obese women,” International Journal of Obesity, vol. 33, no. 1, pp. 151–156, 2009. View at Publisher · View at Google Scholar · View at Scopus
  24. M. C. Hochberg, “Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus,” Arthritis and Rheumatism, vol. 40, no. 9, p. 1725, 1997. View at Publisher · View at Google Scholar
  25. S. Miyakis, M. D. Lockshin, T. Atsumi et al., “International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS),” Journal of Thrombosis and Haemostasis, vol. 4, no. 2, pp. 295–306, 2006. View at Publisher · View at Google Scholar · View at Scopus
  26. G. Howard, A. R. Sharrett, G. Heiss et al., “Carotid artery intimal-medial thickness distribution in general populations as evaluated by B-mode ultrasound. ARIC Investigators,” Stroke, vol. 24, no. 9, pp. 1297–1304, 1993. View at Publisher · View at Google Scholar
  27. S. Ebrahim, O. Papacosta, P. Whincup et al., “Carotid plaque, intima media thickness, cardiovascular risk factors, and prevalent cardiovascular disease in men and women,” Stroke, vol. 30, no. 4, pp. 841–850, 1999. View at Publisher · View at Google Scholar
  28. S. Homma, N. Hirose, H. Ishida, T. Ishii, and G. Araki, “Carotid plaque and intima-media thickness assessed by B-mode ultrasonography in subjects ranging from young adults to centenarians,” Stroke, vol. 32, no. 4, pp. 830–835, 2001. View at Publisher · View at Google Scholar
  29. K. Fischer, “Risk factors of thickened intima-media and atherosclerotic plaque development in carotid arteries in patients with systemic lupus erythematosus,” Annales Academiae Medicae Stetinensis, vol. 54, no. 2, pp. 22–32, 2008. View at Google Scholar
  30. P. G. Vlachoyiannopoulos, P. G. Kanellopoulos, J. P. A. Ioannidis, M. G. Tektonidou, I. Mastorakou, and H. M. Moutsopoulos, “Atherosclerosis in premenopausal women with antiphospholipid syndrome and systemic lupus erythematosus: a controlled study,” Rheumatology, vol. 42, no. 5, pp. 645–651, 2003. View at Publisher · View at Google Scholar · View at Scopus
  31. D. Sacks, C. W. Bakal, P. T. Beatty et al., “Position statement on the use of the anklebrachial index in the evaluation of patients with peripheral vascular disease,” Journal of Vascular and Interventional Radiology, vol. 13, p. 1353, 2002. View at Publisher · View at Google Scholar
  32. H. Przepiera-Będzak, K. Fischer, and M. Brzosko, “Serum levels of angiogenic cytokines in psoriatic arthritis and SAPHO syndrome,” Polish Archives of Internal Medicine, vol. 123, no. 6, pp. 297–302, 2013. View at Publisher · View at Google Scholar
  33. H. Przepiera-Będzak, K. Fischer, and M. Brzosko, “Serum VEGF, EGF, basic FGF, and acidic FGF levels and their association with disease activity and extra-articular symptoms in ankylosing spondylitis,” Polish Archives of Internal Medicine, vol. 126, no. 4, pp. 290–292, 2016. View at Publisher · View at Google Scholar · View at Scopus
  34. K. Fischer and M. Brzosko, “Diagnosis of early atherosclerotic lesions, and selected atherosclerotic risk factors, in patients with systemic lupus erythematosus,” Polish Archives of Internal Medicine, vol. 119, no. 11, pp. 736–741, 2009. View at Google Scholar
  35. M. Khojasteh-Fard, M. Abolhalaj, P. Amiri et al., “IL-23 gene expression in PBMCs of patients with coronary artery disease,” Disease Markers, vol. 33, no. 6, pp. 289–293, 2012. View at Publisher · View at Google Scholar
  36. X. Cheng, X. Yu, Y. J. Ding et al., “The Th17/Treg imbalance in patients with acute coronary syndrome,” Clinical Immunology, vol. 127, no. 1, pp. 89–97, 2008. View at Publisher · View at Google Scholar · View at Scopus
  37. Y. Asanuma, C. P. Chung, A. Oeser et al., “Increased concentration of proatherogenic inflammatory cytokines in systemic lupus erythematosus: relationship to cardiovascular risk factors,” The Journal of Rheumatology, vol. 33, no. 3, pp. 539–545, 2006. View at Google Scholar
  38. M. Zhu, H. Mo, X. Li, and L. Zhang, “Th17/Treg imbalance induced by increased incidence of atherosclerosis in patients with systemic lupus erythematosus (SLE),” Clinical Rheumatology, vol. 32, no. 7, pp. 1045–1052, 2013. View at Publisher · View at Google Scholar · View at Scopus
  39. D.-Y. Chen, Y.-M. Chen, M.-C. Wen, T.-Y. Hsieh, W.-T. Hung, and J.-L. Lan, “The potential role of Th17 cells and Th17-related cytokines in the pathogenesis of lupus nephritis,” Lupus, vol. 21, no. 13, pp. 1385–1396, 2012. View at Publisher · View at Google Scholar · View at Scopus
  40. A. Zickert, P. Amoudruz, Y. Sundström, J. Rönnelid, V. Malmström, and I. Gunnarsson, “IL-17 and IL-23 in lupus nephritis - association to histopathology and response to treatment,” BMC Immunology, vol. 16, no. 7, p. 10, 2015. View at Publisher · View at Google Scholar · View at Scopus
  41. L. P. Xia, B. F. Li, H. Shen, and J. Lu, “Interleukin-27 and interleukin-23 in patients with systemic lupus erythematosus: possible role in lupus nephritis,” Scandinavian Journal of Rheumatology, vol. 44, no. 3, pp. 200–205, 2015. View at Publisher · View at Google Scholar · View at Scopus
  42. F. Qiu, L. Song, N. Yang, and X. Li, “Glucocorticoid downregulates expression of IL-12 family cytokines in systemic lupus erythematosus patients,” Lupus, vol. 22, no. 10, pp. 1011–1016, 2013. View at Publisher · View at Google Scholar · View at Scopus
  43. A. Walecka, M. Sawicki, M. Brzosko, L. Ostanek, K. Fischer, and J. Kordowski, “Value of high resistance index - HRI calculated from Doppler spectrum of popliteal arteries in patients with systemic lupus erythematosus (SLE),” Medical Science Monitor, vol. 10, Supplement 3, pp. 58–62, 2004. View at Google Scholar