Toll-Like Receptor 9 Promotes Survival in SERCA2a KO Heart Failure Mice

Table 2

Organ weight of SERCA2a KO, SERCA2a/TLR9 KO, and control mice 7.6 weeks after gene excision.

Organ weight (mg/TL)	Controls		HF
	WT ()	TLR9 KO ()	SERCA2a KO (23-24)	SERCA2a/TLR9 KO (11–14)
Lung	8.0 ± 0.2	8.3 ± 0.3	10.4 ± 0.3^##	10.8 ± 0.5^##
Liver	63.5 ± 6.5	61.6 ± 3.6	58.9 ± 1.9	64.4 ± 2.9
Right ventricle	1.1 ± 0.07	1.1 ± 0.10	1.3 ± 0.04	1.2 ± 0.07
Total heart	5.7 ± 0.2	6.3 ± 0.5	5.7 ± 0.1	5.9 ± 0.2

TL: tibia length (mm). The groups were compared using two-way ANOVA and Tukey’s multiple comparison test. Data are mean ± SEM. versus the WT control and ^## versus the TLR9 KO control.