MicroRNA-146a Alleviates Experimental Autoimmune Anterior Uveitis in the Eyes of Lewis Rats

Figure 2

Effect of miR-146a on inflammatory cells in aqueous humor and iris and ciliary body tissues. (a) Quantification of leukocytes in the aqueous humor at 7, 10, 15, and 25 dpi. EAAU rats treated with low-dose or high-dose miR-146a had significantly lower leukocyte counts in the aqueous humor. Data are expressed as means ± SD ( compared with the MAA group; compared with the low-dose miR-146a group). (b) Representative hematoxylin and eosin-stained sections of the iris and ciliary body of rats from the five groups. No leukocytes were seen in the control group. Profound leukocyte infiltration was noted on tissue sections from rats treated with MAA or MAA-negative mimic. The cellular response was attenuated by treatment with low-dose or high-dose miR-146a in a dose-dependent manner. Ctrl = control; MAA = melanin-associated antigen; miR-146a L = low-dose miR-146a; miR-146 H = high-dose miR146a.

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