Protease Domain Cell type Substrate or interaction partner Process Reference ADAM8 D, CR Endothelial cells PECAM-1, isolectin B4, Tie2, VEGFR1/2, EphB2, VE-cadherin Angiogenesis [138 , 139 ] ADAM9 MP Keratinocytes Collagen XVII, Reduced migration/wound healing [140 –142 ] MP Epithelial cells EGFR ligands Migration [143 ] MP Vascular smooth muscle cells HB-EGF Migration [144 ] D, CR Fibroblasts Cell-cell interaction and ECM degrading capacity [142 ] ADAM10 MP Epithelial cells Betacellulin Migration [90 ] MP Trophoblasts c-met Block of invasion [145 ] MP Glial precursor cells CXCL16 Migration, invasion [71 ] MP Mesangial cells CXCL16 Migration [146 ] MP Endothelial cells CXCL16, CX3CL1 Chemotaxis, migration, transmigration [22 , 64 –67 , 121 , 123 ] ? Fibroblast-like synoviocytes Cytoskeletal rearrangement, VEGFA, MMP1 and MMP3 expression, CX3CL1 Migration [73 , 120 ] MP Epithelial cells DDR1 Collagen-adhesion, migration [147 ] MP Vascular smooth muscle cells DDR1 Migration [148 ] MP Epithelial cells E-cadherin Transmigration, keratinocyte migration [61 ] MP Neural cells L1CAM Migration [149 , 150 ] MP Endothelial cells, epithelial cells Meprin A, meprin B Transmigration (ECM degradation) [75 –78 ] MP Neural progenitor cells N-cadherin Migration [151 ] MP, ? Vascular smooth muscle cells N-cadherin, Migration [131 ] MP Endometriotic cells Neuregulins Migration [152 ] MP Border cells Notch Migration [153 ] MP Endothelial cells Notch Limitation of vascular sprouting [154 –157 ] MP Vascular smooth muscle cells Notch1, Notch3 Migration [158 ] MP Pericytes, smooth muscle cells PDGFR Migration [159 ] MP Endothelial cells, epithelial cells RAGE Block of transmigration [79 , 80 , 82 ] MP Endothelial cells VE-cadherin Transmigration [59 , 60 ] MP Endothelial cells VEGFR2 Limitation of sprouting [60 , 160 ] ADAM12 MP Trophoblasts ? Cell invasion placental development [161 ] MP Keratinocytes HB-EGF, IGF Migration [162 ] MP Endothelial cells VEGFR2 Limitation of sprouting [163 ] ADAM13 MP Cranial neural crest Cadherin-11 Migration (avoidance of contact inhibition) [164 ] ADAM15 ? Intestinal epithelial cells ? Inhibition of migration (wound healing) [165 ] MP Glomerular mesangial cells Collagen IV, gelatin, fibronectin Migration (matrix degradation) [166 ] ? Fibroblast-like synoviocytes VEGFA, MMP1, and MMP3 expression Migration [124 ] D, ? Endothelial cells Angiogenesis, transmigration [107 –109 , 125 , 167 –169 ] D Airway smooth muscle cells Adhesion, migration [170 ] ADAM17 MP Endothelial cells ALCAM Block of transmigration [83 –85 ] ADAM17 MP Endometriotic cells Amphiregulin Migration [152 ] MP Mesenchymal progenitors Amphiregulin Migration [171 ] MP Trophoblasts c-met Block of invasion [145 ] MP Endothelial cells CX3CL1 Transmigration, chemotaxis [67 , 117 ] MP Mesangial cells CXCL16 Migration [146 ] MP Endothelial cells HB-EGF Migration [17 , 172 ] MP Endothelial cells JAM-A Block of leukocyte transmigration and endothelial migration [62 , 63 ] MP Neural progenitor cells L1-CAM, HB-EGF Migration [150 , 173 ] MP Pericytes, smooth muscle cells PDGFRβ -EGFR crosstalk Migration [159 ] MP Epithelial cells Syndecan-1 Migration [174 , 175 ] MP Epithelial cells (e.g., keratinocytes) TGF Migration [17 , 172 , 176 ] MP Endothelial cells TNF Time-dependent regulation of angiogenesis [177 –180 ] MP Epithelial cells TNFR Migration [181 ] MP Endothelial cells VE-cadherin Transmigration [17 , 60 ] MP Endothelial cells VEGFR2 Angiogenesis [182 ]
