Blockade or antibody-mediated depletion in circulating platelets was shown to effectively inhibit experimental thrombosis, and thromboinflammatory disease states, such as stroke, discuss the potential use of anti-GPVI agents to treat these pathologies in humans [166]
Collagen receptor glycoprotein VI is a key trigger for platelet microparticle generation in arthritis pathophysiology [58]
Proinflammatory cytokine associated with pathology in rheumatoid arthritis. Lymphotoxin alpha beta is required for differentiation of type 1 natural killer T (NKT) cells, a lymphocyte subset with important immunoregulatory properties [62, 63]