Review Article

Recent Advances in ADAM17 Research: A Promising Target for Cancer and Inflammation

Table 3

Substrates involved in inflammation.

SubstrateRole in inflammation

IL-1 receptor2 [49]A decoy receptor that binds IL-1A, IL-1B, and IL-1Ra

Neogenin [50]Endogenous repression of neogenin demonstrates attenuated changes of acute inflammation and inflammatory peritonitis [51]
The guidance receptor neogenin promotes pulmonary inflammation during lung injury [52]
Inhibition of neogenin dampens hepatic ischemia-reperfusion injury [165]

Syndecan-4 [56]Using SDC4āˆ’/āˆ’ mice and an antibody that inhibits SDC4 signaling, airway inflammation was reduced in a murine asthma model [55]

Glycoprotein VI (GPVI) [59, 60]Blockade or antibody-mediated depletion in circulating platelets was shown to effectively inhibit experimental thrombosis, and thromboinflammatory disease states, such as stroke, discuss the potential use of anti-GPVI agents to treat these pathologies in humans [166]
Collagen receptor glycoprotein VI is a key trigger for platelet microparticle generation in arthritis pathophysiology [58]

LTalphabeta (lymphotoxin alpha beta) [61]Proinflammatory cytokine associated with pathology in rheumatoid arthritis. Lymphotoxin alpha beta is required for differentiation of type 1 natural killer T (NKT) cells, a lymphocyte subset with important immunoregulatory properties [62, 63]