Influence of TNF and IL17 Gene Polymorphisms on the Spondyloarthritis Immunopathogenesis, Regardless of HLA-B27, in a Brazilian Population

Table 3

Association of TNF-308, IL17A, and IL17F with the risk of spondyloarthritis, stratified by gender and HLA-B27 marker.

Gene (SNP)	Allele genotypes	SpA () [n (%)]	Controls ( [n (%)]	value^1	OR (95% CI)
TNF-308 (rs1800629)	G/G	144 (59.3)	150 (71.4)
	G/A	95 (39.1)	58 (27.6)
	A/A	4 (1.6)	2 (1.0)
	G/A + A/A	99 (40.7)	60 (28.6)	0.01	1.7 (1.1–2.5)
		()	()
IL17A (rs2275913)	G/G	114 (46.9)	123 (58.6)
	G/A	102 (42.0)	71 (33.8)
	A/A	27 (11.1)	16 (7.6)
	G/A + A/A	129 (53.1)	87 (41.4)	0.005	1.7 (1.2–2.6)
		()	()
IL17F (rs763780)	T/T	161 (66.5)	188 (90.0)
	T/C	76 (31.4)	20 (9.6)
	C/C	5 (2.1)	1 (0.5)
	T/C + C/C	81 (33.5)	21 (10.1)	<0.001	4.5 (2.6–7.6)

SNP: single-nucleotide polymorphism; SpA: spondyloarthritis; OR: odds ratio; CI: confidence interval. ¹Statistical analysis was performed by SNPStats software based on a statistical dominant model.