Dexmedetomidine Inhibits Voltage-Gated Sodium Channels via α2-Adrenoceptors in Trigeminal Ganglion Neurons

Figure 3

Effects of dexmedetomidine on action potentials (APs) in small-sized TG neurons. (a) Dexmedetomidine (100 μM) suppresses APs following current injection (5 ms, 150 pA) in small-sized TG neurons. Traces of single action potentials before (control) and after treatment with dexmedetomidine (5 and 100 μM). (b) Percent inhibition of AP amplitude by dexmedetomidine (5 and 100 μM). ; t-test versus control; and 20 neurons per group, respectively. n.s.: no significance. (c) Dexmedetomidine inhibits the AP frequency after current injection (1 s, 150 pA) in small-sized TG neurons. Traces of action potentials before (control) and after treatment with dexmedetomidine (100 μM). (d) Dexmedetomidine (100 μM) markedly suppresses 90% of the AP frequency after current injection (150 pA) ; t-test versus control; and 20 neurons per group, respectively

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