Raet1e Polymorphisms Are Associated with Increased Risk of Developing Premature Coronary Artery Disease and with Some Cardiometabolic Parameters: The GEA Mexican Study
Table 3
Association of raet1e gene polymorphisms with clinical and metabolic parameters in the coronary patient group.
Polymorphism
(genotype frequency)
MAF
Model
OR [95% CI]
Coronary patients
Hypertension
rs9371533
AA
AG
GG
Additive
1.264 [1.054-1.515]
0.012
No ()
113 (0.305)
188 (0.508)
69 (0.186)
0.441
Recessive
1.501 [1.092-2.063]
0.012
Yes ()
201 (0.255)
397 (0.504)
190 (0.241)
0.493
Codominant 2
1.629 [1.125-2.358]
0.010
Total
rs9371533
AA
AG
GG
No ()
261 (0.282)
448 (0.485)
215 (0.233)
0.475
Heterozygote
1.437 [1.071-1.926]
0.016
Yes ()
53 (0.226)
137 (0.585)
44 (0.188)
0.481
rs2151910
TT
TA
AA
No ()
426 (0.461)
391 (0.423)
107 (0.116)
0.327
Heterozygote
1.515 [1.133-2.027]
0.005
Yes ()
88 (0.376)
125 (0.534)
21 (0.090)
0.357
Codominant 1
1.508 [1.108-2.053]
0.009
GGT > p75
rs7756850
CC
CG
GG
No ()
166 (0.287)
273 (0.471)
140 (0.242)
0.478
Codominant 1
1.436 [1.080-1.909]
0.013
Yes ()
131 (0.227)
312 (0.538)
136 (0.234)
0.504
rs9383921
CC
CT
TT
No ()
168 (0.290)
273 (0.471)
138 (0.238)
0.474
Codominant 1
1.432 [1.078-1.903]
0.013
Yes ()
133 (0.229)
311 (0.538)
135 (0.233)
0.502
Low adiponectin
rs7756850
CC
CG
GG
Additive
1.237 [1.042-1.467]
0.015
No ()
137 (0.278)
257 (0.523)
98 (0.200)
0.460
Recessive
1.493 [1.119-1.991]
0.006
Yes ()
163 (0.244)
324 (0.487)
179 (0.269)
0.512
Codominant 2
1.538 [1.096-2.185]
0.013
rs9383921
CC
CT
TT
Additive
1.257 [1.059-1.490]
0.009
No ()
140 (0.284)
256 (0.521)
96 (0.195)
0.455
Recessive
1.509 [1.129-2.016]
0.005
Yes ()
161 (0.242)
326 (0.490)
179 (0.268)
0.514
Codominant 2
1.600 [1.132-2.260]
0.008
Data are expressed as odds ratio (OR) and 95% confidence interval (CI) as assessed by multivariate logistic regression analyses. All models were adjusted by age, gender, and body mass index. MAF = minor allele frequency; GGT = gamma-glutamyltransferase.
