Mediators of Inflammation

Research Article

Are Thyroid Autoimmune Diseases Associated with Cardiometabolic Risks in a Population with Normal Thyroid-Stimulating Hormone?

Table 3

Characteristic of subjects in terms of TPOAb, TgAb, and US.


	TPO and TgAb (−)	TPO/TgAb (+) and US (+)	value

Men
(%)	3426 (89.9)	134 (3.5)	—
Age (year)	53.80 ± 13.04	54.52 ± 13.09	0.527
Smokers (%)	55.6	49.6	0.177
Systolic BP (mmHg)	134.36 ± 20.81	135.56 ± 20.68	0.516
BMI (kg/m²)	24.83 ± 3.35	25.75 ± 3.45	0.002
WC (cm)	84.26 ± 9.60	86.21 ± 9.29	0.022
FPG (mmol/L)	5.72 ± 1.56	5.22 ± 1.18	0.185
HOMA-IR	1.49 ± 2.32	1.43 ± 0.98	0.038
HbA1c (%)	5.62 ± 1.02	5.61 ± 0.89	0.721
LDL (mmol/L)	3.07 ± 0.76	3.14 ± 0.68	0.351
HDL (mmol/L)	1.36 ± 0.32	1.34 ± 0.31	0.543
TG (mmol/L)	1.91 ± 1.99	1.84 ± 1.22	0.187
TC (mmol/L)	5.16 ± 1.13	5.22 ± 1.18	0.536
TSH (mIU/L)	2.11 ± 0.91	2.56 ± 1.02	<0.001
T₃ (nmol/L)	1.77 ± 0.42	1.73 ± 0.36	0.127
T₄ (nmol/L)	113.59 ± 22.30	110.13 ± 19.24	0.077
Hyperlipidemia (%)	42.7	49.3	0.130
Diabetes (%)	15.0	17.9	0.363
Hypertension (%)	51.6	50.8	0.852
Metabolic syndrome (%)	20.5	24.6	0.257
Cardiovascular events (%)	7.2	9.0	0.429
Women
(%)	3970 (79.4)	517 (10.3)	—
Age (year)	52.45 ± 13.16	54.56 ± 12.31	<0.001
Smokers (%)	2.9	1.4	0.053
Systolic BP (mmHg)	129.93 ± 22.07	132.72 ± 23.65	0.008
BMI (kg/m²)	24.16 ± 3.56	25.11 ± 3.73	0.002
WC (cm)	77.53 ± 10.00	80.32 ± 10.05	<0.001
FPG (mmol/L)	5.55 ± 1.30	5.67 ± 1.53	0.061
HOMA-IR	1.53 ± 1.77	1.78 ± 2.86	<0.001
HbA1c (%)	5.43 ± 0.87	5.59 ± 0.99	<0.001
LDL (mmol/L)	3.05 ± 0.79	3.11 ± 0.81	0.084
HDL (mmol/L)	1.48 ± 0.32	1.46 ± 0.31	0.088
TG (mmol/L)	1.46 ± 1.04	1.71 ± 1.88	<0.001
TC (mmol/L)	5.14 ± 1.16	5.20 ± 1.03	0.280
TSH (mIU/L)	2.43 ± 0.99	2.68 ± 1.05	<0.001
T₃ (nmol/L)	1.72 ± 0.36	1.75 ± 0.53	0.644
T₄ (nmol/L)	115.10 ± 19.16	115.31 ± 21.45	0.833
Hyperlipidemia (%)	30.4	38.9	<0.001
Diabetes (%)	11.5	15.7	0.006
Hypertension (%)	40.6	46.4	0.013
Metabolic syndrome (%)	25.5	35.8	<0.001
Cardiovascular events (%)	7.4	10.1	0.033

Data are presented as the mean ± standard deviation for continuous variables or as a percentage (%) for categorical variables. BP, blood pressure; BMI, body mass index; WC, waist circumference; FPG, fasting blood glucose; HOMA-IR, homeostasis model assessment of insulin resistance; HbA1c, glycated hemoglobin; LDL, low-density lipoprotein; HDL, high-density lipoprotein; TG, triglycerides; TC, total cholesterol; TSH, thyroid-stimulating hormone; T₃, triiodothyronine; T₄, thyroxin.