Salivary Gland Extract of Kissing Bug, Triatoma lecticularia, Reduces the Severity of Intestinal Inflammation through the Modulation of the Local IL-6/IL-10 Axis

Figure 3

T. lecticularia SGE improves histopathological alterations in mice exposed to DSS. Intestinal inflammation was induced by free consumption of drinking water containing 3% DSS for 6 consecutive days. Mice were treated i.p. with 100 μl of saline or T. lecticularia SGE (3, 10, or 30 μg/animal/day). (a) Mice exposed to DSS: lamina propria with moderate edema (asterisk) and intense mononuclear cell infiltration (black arrow) and submucosa with moderate mononuclear infiltrate (black arrow) and intense edema (asterisk). Severely damaged crypts (white arrow); (b) mice exposed to DSS and treated with T. lecticularia SGE (3 μg/animal/day): lamina propria with moderate edema (asterisk) and mononuclear cell infiltration (black arrow) and submucosa with moderate mononuclear infiltrate (black arrow) and moderate edema (asterisk). Severely damaged crypts (white arrow); (c) mice exposed to DSS and treated with T. lecticularia SGE (10 μg/animal/day): lamina propria with discrete edema (asterisk) and mononuclear cell infiltration (black arrow) and submucosa with discrete mononuclear infiltrate (black arrow) and edema (asterisk). Dilated crypts (white arrow); (d) mice exposed to DSS and treated with T. lecticularia SGE (30 μg/animal/day): lamina propria with discrete edema (asterisk) and mononuclear cell infiltration (black arrow) and submucosa with moderate mononuclear infiltrate (black arrow) and edema (asterisk). Partly damaged or dilated crypts (white arrow). Results are representative of two independent experiments ( mice/group).

(a)

(b)

(c)

(d)