Metabolic Derangements Contribute to Reduced sRAGE Isoforms in Subjects with Alzheimer’s Disease

Figure 1

Attenuated cRAGE : esRAGE ratio with Alzheimer’s disease compared to individuals with normal cognition. (a) Total sRAGE and (c) esRAGE were measured using commercially available ELISAs. (b) cRAGE was calculated by subtracting esRAGE from total sRAGE and the (d) cRAGE : esRAGE ratio was calculated by division. Data are presented as mean ± SEM. Sample sizes for the stratifications are as follows: NC () and AD (). versus NC.

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