Low-Copy Number Polymorphism in DEFA1/DEFA3 Is Associated with Susceptibility to Hospital-Acquired Infections in Critically Ill Patients

Table 1

Basic characteristics of two groups at ICU admission.

Characteristics	HAIs ()	Controls ()	value
Age (yr), mean ± SD	61.96 ± 14.24	61.98 ± 13.37	0.992
Male sex, n (%)	74 (69.8%)	66 (60.6%)	0.198
Source of ICU admittance, n (%)			0.02
Emergency department	38 (35.8%)	20 (18.3%)
General ward	9 (8.5%)	7 (6.4%)
Operating or recovery room	55 (51.9%)	82 (75.2%)
Other ICU	4 (3.8%)	0 (0%)
APS score, median, IQR	11 (7–18.25)	6 (5–12)	<0.001
APACHE II, median, IQR	16 (11–22)	11 (8–16)	<0.001
SOFA, median, IQR	5 (1–7)	3 (1–6)	0.024
Length of hospital stay (days), median, IQR	24 (16–34)	16 (11–26)	<0.001
Length of ICU stay (days), median, IQR	11 (5–17)	4 (2–5)	<0.001
28-day mortality, n (%)	14 (13.2%)	8 (7.4%)	0.181

HAIs: hospital-acquired infections; n: number of subjects; APS: Acute Physiology Score, APACHE II: Acute Physiology and Chronic Health Evaluation score II; SOFA: Sequential Organ Failure Assessment score. Values are presented as the mean ± standard deviation (SD), median (interquartile range (IQR)), or n (%). Continuous variables with normal distribution are presented as the “mean ± SD”; continuous variables with abnormal distribution are presented as the “median, IQR”; categorical variables are presented as “n (%).” Each value < 0.05 was considered to be significant. The value was obtained by t-test or Mann–Whitney test for continuous variables and chi-square test for categorical variables.