Diabetes Mellitus and Liver Surgery: The Effect of Diabetes on Oxidative Stress and Inflammation

Figure 1

Mechanisms of OS in the promotion of liver damage and impaired regeneration after liver surgery in association with DM. The illustration shows the molecular events subsequent to the surgical procedure performed on the diabetic liver, which leads to a significant increase of ROS, inducing liver injury and regeneration. PH, partial hepatectomy; I/R, ischaemia-reperfusion; O₂^-, superoxide anion; HSP, heat shock protein; NF-κB, nuclear factor kappa B; Nrf2, nuclear factor (erythroid-derived 2)-like-2 factor; H₂O₂, hydrogen peroxide; •OH, hydroxyl radical.