Table 3: Effects of gamma linolenic (GLA) fatty acid.

Fatty acidConditionStudy modelTreatment timeDose/concentrationMolecules associatedEffect in tissue repairReference

GLAAcne vulgarisHealthy humans10 weeks400 mg (oral administration)Reduced IL-8Reduced lesion number, severity, and inflammation[88]
Atopic dermatitis (AD)Humans12 weeks320 or 480 mg (oral administration)NAImprovement of clinical signs of AD[89]
Macrophage functionsRAW 264.7 macrophages‚ÄČ100 to 200 μM (in vitro)Reduced iNOS, NO, COX-2, pro-IL-1, pIκB, and NF-κBDecreased inflammation[90]

Interleukin-8 (IL-8); inducible nitric oxide synthase (iNOS); oxide nitric (NO); cicloxigenase-2 (COX-2); prointerleukin-1 (pro-IL-1); nuclear transcription factor (NF-κB); not analysed (NA)