Wound Healing and Omega-6 Fatty Acids: From Inflammation to Repair

Table 3

Effects of gamma linolenic (GLA) fatty acid.

Fatty acid	Condition	Study model	Treatment time	Dose/concentration	Molecules associated	Effect in tissue repair	Reference
GLA	Acne vulgaris	Healthy humans	10 weeks	400 mg (oral administration)	Reduced IL-8	Reduced lesion number, severity, and inflammation	[88]
	Atopic dermatitis (AD)	Humans	12 weeks	320 or 480 mg (oral administration)	NA	Improvement of clinical signs of AD	[89]
	Macrophage functions	RAW 264.7 macrophages		100 to 200 μM (in vitro)	Reduced iNOS, NO, COX-2, pro-IL-1, pIκB, and NF-κB	Decreased inflammation	[90]

Interleukin-8 (IL-8); inducible nitric oxide synthase (iNOS); oxide nitric (NO); cicloxigenase-2 (COX-2); prointerleukin-1 (pro-IL-1); nuclear transcription factor (NF-κB); not analysed (NA)