Contribution of Neurons and Glial Cells to Complement-Mediated Synapse Removal during Development, Aging and in Alzheimer’s Disease

Table 1

Cellular localization of complement components during development.

Cell type	Localization	Experimental model	Method	Ref.
C1q
Neuron	Synaptic puncta, axons	In vitro: rat primary culture; In vivo: C1qaKO, Tgfbr2^−/−, C1qa^−/− mice	qRT-PCR, in situ hybridization, ICC, IHC, WB	[4, 5]
C3
Unknown	Synaptic puncta	In vivo: C3KO mice	IHC	[4, 15]
CR3
Microglia	Cell surface	In vivo: CR3KO mice	IHC	[15]

qRT-PCR: semiquantitative PCR; ICC: immunocytochemistry; IHC: immunohistochemistry; WB: Western blot.