|
| Host | Infiltrated immune cells | Inflammatory mediators on the ocular surface | References |
|
| Human (15 NS-KCS patients) | CD4+ and CD8+ | ⬆ ICAM-1 | 17 |
| Human (5 moderate DED patients) | CEC | ⬆ nondifferences (IL-1β, IL-8, IL-6, and ICAM) | 69 |
| Human (30 dysfunctional tear syndrome patients) | ND | ⬆ IL-6, IL-8, and TNF-α | 3 |
| Human (23 evaporative-type DED patients (46 eyes)) | ND | ⬆ IL-1Ra, IL-6, and CXCL/IL-8 | 70 |
| Human (17 DED patients) | CD4+ | ⬆ CXCL9, 10, 11, and CXCR3 | 48 |
| Human (35 aqueous-deficient dry eye DRY-aq patients, 36 lipid layer-deficient DRYlip patients, and 34 in combination of both (DRYaplip)) | ND | ⬆ IL-1β, IL-6, IL-8, TNF-α, and IFN-γ | 71 |
| Human (DED patients) | ND | ⬆ IL-1β, IL-6, INF-γ, and TNF-α | 72 |
| Human (70 patients) | ND | ⬆ IFN-γ | 73 |
| Human (34 DED patients with HIV infection and 32 DED patients without HIV infection) | ND | ⬆ EGF, IFN-gamma-inducible protein 10 (IP-10, CXCL10) | 74 |
| Human (19 diabetic patients with DED and 15 nondiabetic patients with DED) | ND | ⬆ IL-β and TNF-α | 75 |
| Human (15 samples in non-SS patients) | ND | ⬆ IL-6, IL-17-A, and IL-23 | 76 |
| Human (DED) | CD4+ and CD8+RM | ⬆ CCR7− TEM | 49 |
| Human (32 patients severe DED) | ND | ⬆ IL-17 and TNF-α | 77 |
| Murine (BALB/c, T cell-deficient nude BALB/c (BALB/cByJHfH11<ʋ>), and C57BL/6) | Neutrophil, mononuclear cell, and CD4+ | ND | 22 |
| Murine (C57Bl/6) | CD4+ | ⬆ IL-6, IL-17 mRNA | 78 |
| Murine (C57BL/6 desiccating stress) | CD4+IL-17+ | ⬆ TNF-α, IL-1β, IL-6, IFN-γ, IL-23, and IL-17A | 53 |
| Murine (C57BL/6) | CD11b+, CD4+IL-IFN-γ+, and CD4+IL-17+ | ⬆ CCR6, CCL20, and IL-17A | 54 |
| Murine | CD11b+ and CD4+IL-17+ | ⬆ IL-17A and GM-CSF | 56 |
| Murine (C57BL/6) | CD4+CXCR3+ T cells | ⬆ IL-1β, Il-6, TNF-α, IFN-γ, and ROS | 79 |
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