Plasma Energy-Balance Metabolites Discriminate Asymptomatic Patients with Peripheral Artery Disease

Table 2

Spearman’s correlation coefficients for PON1 concentration, PON1 paraoxonase activity, PON1 lactonase activity, CCL2 concentration, and related metabolites.

	PON1 concentration		Paraoxonase activity		Lactonase activity		CCL2 concentration
	Spearman’s rho	value	Spearman’s rho	value	Spearman’s rho	value	Spearman’s rho	value
3-hydroxybutirate	−0.640	<0.001	−0.309	<0.001	−0.496	<0.001	0.241	0.009
α-Ketoglutarate	−0.021	ns	−0.183	0.029	−0.029	ns	−0.045	ns
Aconitate	−0.641	<0.001	−0.394	<0.001	−0.552	<0.001	0.345	<0.001
Alanine	0.153	ns	0.253	0.002	0.275	0.001	−0.155	ns
Aspartate	−0.241	0.004	−0.187	0.026	−0.349	<0.001	0.184	0.046
(Iso)citrate	−0.592	<0.001	−0.166	0.048	−0.381	<0.001	0.303	0.001
Fumarate	0.295	<0.001	−0.053	ns	0.166	0.048	−0.014	ns
Glucose	0.011	ns	0.109	ns	0.053	ns	−0.098	ns
Glutamate	−0.590	<0.001	−0.425	<0.001	−0.589	<0.001	.0171	ns
Glutamine	−0.263	0.002	−0.059	ns	−0.198	0.018	0.187	0.043
Isoleucine	−0.342	<0.001	−0.101	ns	−0.299	<0.001	0.167	ns
Lactate	0.277	0.001	0.086	ns	0.175	0.036	−0.104	ns
Leucine	−0.229	0.006	0.008	ns	−0.136	ns	0.079	ns
Malate	−0.356	<0.001	−0.240	0.004	−0.279	0.001	0.225	0.014
Pyruvate	0.356	<0.001	−0.034	ns	0.158	ns	−0.163	ns
Serine	−0.595	<0.001	−0.294	<0.001	−0.534	<0.001	0.295	0.001
Succinate	−0.355	<0.001	−0.194	0.021	−0.342	<0.001	0.110	ns
Succinyl-CoA	−0.223	0.008	−0.101	ns	−0.154	ns	0.025	ns
Valine	−0.035	ns	0.155	ns	0.076	ns	−0.009	ns

PON1: Paraoxonase 1; CCL2: chemokine (C-C) motif ligand 2; ns: not significant.