Upregulation of Cardiac IL-10 and Downregulation of IFN-γ in Balb/c IL-4^−/− in Acute Chagasic Myocarditis due to Colombian Strain of Trypanosoma cruzi

Figure 2

Expression of proinflammatory cytokines in cardiac tissue and serum of Balb/c WT and Balb/c IL-4^−/− mice infected and not infected with the Colombian strain of T. cruzi in the acute phase of experimental Chagas’ disease. (a) Tissue IFN-γ production (pg/g). (b) Tissue TNF-α production (pg/g). (c) Serum levels of TNF-α (pg/ml). (d) Tissue IL12p70 production (pg/g). Student’s -test. Bars represent the mean, and vertical lines represent the standard error. Significant differences between infected versus uninfected animals. ^ΔSignificant differences between the WT versus IL-4^−/− group.

(a)

(b)

(c)

(d)