Reduction of Glucocorticoid Receptor Function in Chronic Fatigue Syndrome

Table 1

Standard deviations for endocrine data between chronic fatigue and healthy participants.

	CFS	Healthy controls	Difference	value
Day 1 AUCg	79.4 (63.1, 97.5)	72.1 (38.3, 113.2)	7.32 (−38.8, 48.4)	0.389
Day 1 AUCi	66.3 (52.9, 81.0)	27.5 (14.9, 43.4)	38.75 (16.9, 60.3)	0.014
Day 2 AUCg	25.4 (20.0, 31.4)	6.8 (3.7, 10.8)	18.61 (11.6, 25.8)	<0.0005
Day 2 AUCi	16.1 (12.7, 19.7)	5.3 (2.8, 8.4)	10.75 (5.9, 15.5)	<0.0005
% suppression TNFα	31.2 (24.3, 39.0)	15.6 (10.5, 21.3)	15.6 (6.1, 25.1)	0.001
% suppression IL-6	18.3 (14.2, 22.9)	13.0 (8.9, 17.9)	5.3 (−1.2, 11.8)	0.054
% suppression IL-10	47.4 (36.5, 59.3)	56.4 (38.2, 78.0)	−9.1 (−33.8, 13.9)	0.774

AUCg: area under the curve with respect to ground; AUCi: area under the curve with respect to increase. The % suppressions refer to the percentage difference in cytokine concentration in the dexamethasone 10 nM condition compared with the LPS condition. Values presented are the mean values of the posterior distribution of standard deviations with 95% credible intervals in brackets. Differences are significant if the credible interval does not include zero. values refer to the proportion of the posterior mean standard deviation difference plot which is less than or equal to zero.