Inflammatory and Immune Proteins in Umbilical Cord Blood: Association with Hearing Screening Test Failure in Preterm Neonates
Table 2
Umbilical cord plasma levels of inflammatory and immune proteins according to newborn hearing screening test results.
Abnormal finding in newborn hearing screening test
Absent ()
Present ()
Umbilical cord plasma IL-6 (pg/mL)
11.0 ± 15.1
19.0 ± 18.7
0.040
Umbilical cord plasma C3a (μg/mL)
11.8 ± 5.9
8.0 ± 5.0
0.017
Umbilical cord plasma C5a (ng/mL)
30.3 ± 22.8
23.6 ± 10.8
0.390
Umbilical cord plasma MMP-9 (ng/mL)
108.0 ± 714.0
83.9 ± 71.2
0.124
Umbilical cord plasma M-CSF (pg/mL)
715.4 ± 390.8
749.7 ± 509.5
0.946
Umbilical cord plasma endostatin (ng/mL)
82.9 ± 16.3
85.6 ± 17.4
0.497
Umbilical cord plasma IL-6 > 11 pg/mL
33 (29.5%)
8 (53.3%)
0.063
Fetal inflammatory response syndromea
43 (38.4.0%)
9 (60.0%)
0.110
Values are given as mean ± standard deviation or n (%). IL: interleukin; MMP: matrix metalloproteinase; M-CSF: macrophage colony-stimulating factor. aFetal inflammatory response syndrome is defined as the presence of funisitis or elevated levels of umbilical cord plasma IL-6 (>11 pg/mL).
