Mediators of Inflammation

Review Article

Phenotypic and Functional Diversities of Myeloid-Derived Suppressor Cells in Autoimmune Diseases

Table 1

Myeloid-derived suppressor cells in autoimmune diseases.


Disease	Species	Phenotype	Mechanism of suppression (in vitro)	Effect in vivo	Reference

Multiple sclerosis	Mouse	CD11b⁺Ly6C^hiLy6G^-	NO apoptosis	Not determined	[8]
	Mouse	CD11b⁺CD62L⁺Ly6C⁺	Undetermined	Proinflammatory	[45]
	Mouse	CCR2⁺CD11b⁺Ly6C^hi	Unknown	Increase severity	[54]
	Mouse	CD11b⁺Gr-1⁺	IL-1β	Increase severity	[55]
	Mouse	CD11b^hiLy6G⁺Ly6C^-	PD-L1	Reduce severity	[56]

Systemic lupus erythematosus	Mouse	CD11b⁺Gr-1^low	Arginase-1	Not determined	[11]
	Mouse	CD11c^-CD11b⁺Gr-1⁺	NO	Suppressor	[46]
	Mouse	CD11b⁺Ly6C^hi	NO, PGE2, cell-cell contact	Possibly protective	[53]
	Human	HLA-DR^-CD11b⁺CD33⁺	Unknown	Increase severity	[58]
	Mouse	Gr-1^hiLy6G⁺CD11b⁺	ROS, NO	Suppressor (in males)	[59]

A lupus-like disease driven by HSP	Mouse	CD11b⁺Gr-1⁺	Unknown	Reduce severity	[57]

Type 1 diabetes	Mouse	CD11b⁺Gr-1⁺	NO, IL-10, cell-cell contact	Reduce severity	[47]
	Mouse	CD11b^hiGr-1^int	Cell-cell contact	Proinflammatory	[60]
	Human	HLA-DR^-CD11b⁺CD33⁺	Cell-cell contact	Proinflammatory	[60]
	Mouse	Gr-1⁺CD115⁺	MHC class II-restricted Ag presentation	Reduce severity	[61]

Inflammatory bowel disease	Mouse	CD11b⁺Gr-1⁺	NO apoptosis	Reduce severity	[9]
Inflammatory bowel disease	Mouse	CD11b⁺Ly6C^hiLy6G^-	NO, cell-cell contact, partially IFN-γ, PGs	Not determined	[48]

Rheumatoid arthritis	Mouse	CD11b⁺Ly6G⁺Ly6C^low	Arg-1, NO	Reduce severity	[49]
	Mouse	CD11c^-CD11b⁺GR-1⁺	IL-10, Arg-1	Reduce severity	[62]
	Human	HLA-DR^-CD11b⁺CD33⁺	Unknown	Suppressor	[66]
	Human	CD11b⁺CD33⁺HLA-DR^-	Unknown	Increase severity	[67]

Inflammatory eye disease	Mouse	CD11b⁺Gr-1⁺Ly6G^-	TNFR-dependent, arginase	Not determined	[51, 52]
Inflammatory eye disease	Mouse	CD11b⁺Gr-1⁺	IL-6	Reduce severity	[70]

Autoimmune hepatitis	Mouse	CD11b⁺Ly6C^hiLy6G^-	NO, IFN-γ, cell-cell contact	Not determined	[50]

Alopecia areata	Mouse	CD11b⁺Gr-1⁺	T cell apoptosis	Possibly protective	[63]

Experimental autoimmune myasthenia gravis	Mouse	CD11b⁺Gr-1⁺	PGE2, NO, Arg-1	Reduce severity	[64]