Research Article

Osthole Protects against Acute Lung Injury by Suppressing NF-κB-Dependent Inflammation

Figure 3

Osthole prolongs survival and inhibits inflammatory cytokines in LPS-induced septic mice. C57BL/6 mice ( each group) were pretreated for 0.5 h with 20 mg/kg or 40 mg/kg osthole via ip injection, followed by 20 mg/kg LPS by iv injection. (a) Percent survival for up to 168 h post-LPS injection is reported as ; ; , versus control (Ctrl), and , versus LPS. (b) Body weight change was monitored for up to 168 h post-LPS injection and reported as ; ; and , versus Ctrl; and , versus LPS. ELISA determination of (c) IL-6 and (b) TNF-α content in serum and lung tissue from septic mice; values are normalized to serum volume (c) or tissue weights (d) and reported as ; ns = not significant, , , and , versus Ctrl. , , and , versus vehicle.
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