Mediators of Inflammation / 2018 / Article / Tab 2

Research Article

Systemic Inflammation Characterizes Lack of Metabolic Health in Nonobese HIV-Infected Men

Table 2

Differences in clinical and laboratory parameters by metabolic health status: BMI < 25 kg/m2.

Metabolically healthyMetabolically unhealthy value
Median (IQR)Median (IQR)

HIV−
Age (years)12455 (50, 62)959 (54, 62)0.41
IL-6 (pg/mL)1151.1 (0.6, 1.8)91.1 (1.0, 1.6)0.55
hs-CRP (μg/mL)1180.8 (0.4, 1.3)91.0 (0.3, 1.2)0.95
sTNFRI (pg/mL)1181075 (914, 1317)9848 (699, 1319)0.25
sTNFRII (pg/mL)1185496 (4737, 6595)95904 (3912, 6065)0.34
sCD163 (ng/mL)113511 (418, 674)9549 (323, 655)0.51
sCD14 (ng/mL)1111341 (1126, 1549)9122 (1158, 1425)0.42
Adiponectin (ng/mL)1179441 (6955, 13399)93654 (3111, 5020)0.001
Leptin (pg/mL)1172958 (1556, 4924)93436 (3082, 3972)0.24
Abdominal VAT area (cm2)12387 (54, 118)9145 (114, 165)0.002
Thigh subcutaneous fat area (cm2)12435 (26, 44)932 (26, 35)0.42
HOMA-IR (mmol/L × μU/mL)1072.0 (2.0, 3.0)93.0 (2.0, 4.0)0.03

HIV+
Age (years)16453 (49, 59)4257 (52, 62)0.02
IL-6 (pg/mL)1591.3 (0.8, 2.1)401.9 (1.1, 2.3)0.03
hs-CRP (μg/mL)1591.1 (0.5, 2.6)401.6 (0.8, 2.9)0.06
sTNFRI (pg/mL)1601151 (948, 1421)411416 (1171, 1811)<0.001
sTNFRII (pg/mL)1606302 (5307, 7531)417126 (6343, 10,467)0.001
sCD163 (ng/mL)150601 (451, 807)37699 (577, 893)0.12
sCD14 (ng/mL)1511728 (1517, 2015)351807 (1539, 2204)0.18
Adiponectin (ng/mL)1588375 (4850, 12,397)404392 (2375, 8370)<0.001
Leptin (pg/mL)1582733 (1540, 5208)403995 (1764, 7720)0.07
Abdominal VAT area (cm2)164108 (62, 154)41182 (139, 217)<0.001
Thigh subcutaneous fat area (cm2)16418 (7, 31)4110 (4, 18)0.001
HOMA-IR (mmol/L × μU/mL)1353.0 (2.0, 3.0)404.0 (3.0, 6.0)<0.001

HOMA-IR: homeostatic model assessment of insulin resistance; hs-CRP: high-sensitivity C-reactive protein; IL-6: interleukin-6; IQR: interquartile range; sCD163: soluble CD163; sCD14: soluble CD14; sTNFRI-II: soluble tumor necrosis factor receptor I-II; VAT: visceral adipose tissue.

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