Activation of GABA_B Receptor Suppresses Diabetic Neuropathic Pain through Toll-Like Receptor 4 Signaling Pathway in the Spinal Dorsal Horn

Figure 4

The protein expression of Myd88, TLR4, and NF-κBp65 in each group. (a) Myd88 in the control (), DNP (), DNP + LPS-RS (TLR4 antagonist, ), DNP + baclofen (GABA_B receptor agonist, ), and DNP + saclofen (GABA_B receptor blocker, ) groups. (b) NF-κBp65 in the control (), DNP (), DNP + LPS-RS (TLR4 antagonist, ), DNP + MIP (Myd88 antagonist, ), DNP + baclofen (GABA_B receptor agonist, ), and DNP + saclofen (GABA_B receptor blocker, ) groups. (c) TLR4 in the control, DNP, DNP + baclofen (GABA_B receptor agonist), and DNP + saclofen (GABA_B receptor blocker) groups. ; .

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