Research Article
Pharmacological Inhibition of Caspase-1 Ameliorates Cisplatin-Induced Nephrotoxicity through Suppression of Apoptosis, Oxidative Stress, and Inflammation in Mice
Figure 5
Effects of Ac-YVAD-cmk on cisplatin-induced inflammatory responses. (a) Representative images of immunohistochemical staining using anti-Mac-2 antibody in the glomerulus. Black arrows indicate Mac-2 positive cells. Scale bar: 25 μm. (b) Percentage of Mac-2 positive cells per glomerulus. Real-time RT-PCR analysis of TNF-α (c), IL-6 (d), MCP-1 (e), and CXCL1 (f) in the kidneys. Con: control, CP: cisplatin, and CP + YVAD: cisplatin plus Ac-YVAD-cmk. per group. All data are expressed as the mean ± SEM. vs. Con. and vs. CP.
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