PICK1 Deficiency Induces Autophagy Dysfunction via Lysosomal Impairment and Amplifies Sepsis-Induced Acute Lung Injury

Figure 3

PICK1 deficiency leads to more serious damage. (a, b) Changes in TNF-α and IL-1β concentrations in BALF between groups. (c) Representative photomicrographs of lung sections stained with H&E at 24 h post-CLP in WT and PICK1^−/− mice (magnification, 200x). (d) Lung wet : dry weight ratio in WT and PICK1^−/− mice. Results represent the mean ± SEM (/group). vs. sham-operated group; vs. CLP mice in the WT group; vs. injection of chloroquine after CLP in the WT group.

(a)

(b)

(c)

(d)

(e)