Apoptosis-Associated Speck-Like Protein Containing a CARD Deletion Ameliorates Unilateral Ureteral Obstruction Induced Renal Fibrosis and Endoplasmic Reticulum Stress in Mice
ASC deletion attenuates UUO-induced renal injury in mice. (a) Representative photomicrographs at 14 days after UUO of PAS-stained sections (magnification, ×400). (b) Masson trichrome-stained kidney sections (magnification, ×400). (c) Glomerular injury scores and (d) tubulointerstitial fibrosis indices evaluated based on PAS and Masson staining; over 20 sections for each group were counted. , WT/sham group versus WT/UUO group. , ASC−/−/UUO group versus WT/UUO group. Data represent the mean ± SEM.