Apoptosis-Associated Speck-Like Protein Containing a CARD Deletion Ameliorates Unilateral Ureteral Obstruction Induced Renal Fibrosis and Endoplasmic Reticulum Stress in Mice
ASC−/− protects against apoptosis associated with UUO. (a) Images of TUNEL staining (magnification, ×200). (b) Average number of TUNEL-positive cells per scope, 10 fields were selected randomly over 6 mice for each group. (c) Immunoblotting for Bcl-2, Bax, and caspase 3 protein expression at day 14 after UUO. (d) Quantification of Bcl-2, Bax, and cleaved caspase 3 levels, normalized against those of β-actin. , WT/sham group versus WT/UUO group. , ASC−/−/UUO group versus WT/UUO group. Data represent the mean ± SEM ().