Apoptosis-Associated Speck-Like Protein Containing a CARD Deletion Ameliorates Unilateral Ureteral Obstruction Induced Renal Fibrosis and Endoplasmic Reticulum Stress in Mice
Renal inflammatory cell infiltration after UUO is reduced in ASC−/− mice. Immunohistochemistry (magnification, ×400) of (a) CD11b-positive leukocytes, (b) F4/80-positive macrophages, and (c) Ly6G-positive granulocytes. (d) Quantification of inflammatory cell infiltration (brown pixels) in renal interstitium. , WT/sham group versus WT/UUO group. , ASC−/−/UUO group versus WT/UUO group. Data represent the mean ± SEM ().