Apoptosis-Associated Speck-Like Protein Containing a CARD Deletion Ameliorates Unilateral Ureteral Obstruction Induced Renal Fibrosis and Endoplasmic Reticulum Stress in Mice

Figure 6

ASC deletion reduces the expression of cytokines that are upregulated by inflammasomes in the UUO model of CKD. (a) Immunoblotting for the level of caspase 1, IL-18, and IL-1β. (b) Quantification analysis of caspase 1, IL-18, and IL-1β levels, normalized against those of β-actin. Semiquantitative analysis of NLRP3, IL-18, and IL-1β (c) and IL-6 and TNF-α gene expression (d) normalized against 18S performed by real-time PCR. , WT/sham group versus WT/UUO group. , ASC^−/−/UUO group versus WT/UUO group. Data represent the mean ± SEM ().

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