A Novel Association of Polymorphism in the ITGA4 Gene Encoding the VLA-4 α4 Subunit with Increased Risk of Alzheimer’s Disease
Table 2
Allele and genotypes frequencies of the ITGA4 −269A/C and +3061A/G polymorphism in AD patients and controls.
SNP/model
Allele/genotype
AD subjects ()
Controls ()
Univariate analysis
Multivariate analysis
OR (95% CI)
OR (95% CI)
−269 C/A
C
170 (81.73%)
339 (82.28%)
—
—
—
—
A
38 (18.27%)
73 (17.72%)
0.87
1.04 (0.67–1.60)
—
—
Codominant
CC
66 (63.46%)
133 (64.56%)
1.00
1.00
CA
38 (36.54%)
73 (35.44%)
0.85
1.05 (0.64–1.71)
1.00
1.00 (0.60–1.68)
AA
0 (00.00%)
0 (00.00%)
—
—
—
—
Dominant
CC
66 (63.46%)
133 (64.56%)
1.00
1.00
CA + AA
38 (36.54%)
73 (35.44%)
0.85
1.05 (0.64–1.71)
1.00
1.00 (0.60–1.68)
Recessive
CC + CA
104 (100.00%)
206 (100.00%)
—
—
—
—
AA
0 (00.00%)
0 (00.00%)
—
—
—
—
+3061 A/G
A
135 (64.90%)
294 (71.36%)
—
—
—
—
G
73 (35.10%)
118 (28.64%)
0.10
1.35 (0.94–1.92)
—
—
Codominant
AA
39 (37.50%)
106 (51.46%)
1.00
1.00
AG
57 (54.81%)
82 (39.80%)
0.04
1.89 (1.15–3.11)
0.11
1.76 (1.04–2.97)
GG
8 (7.70%)
18 (8.74%)
—
1.21 (0.49–3.00)
—
1.35 (0.52–3.51)
Dominant
AA
39 (37.50%)
106 (51.46%)
1.00
1.00
AG + GG
65 (62.50%)
100 (48.54%)
0.02
1.77 (1.09–2.86)
0.04
1.69 (1.02–2.81)
Recessive
AA + AG
96 (92.31%)
188 (91.26%)
1.00
1.00
GG
8 (7.69%)
18 (8.74%)
0.75
0.87 (0.37–2.07)
0.99
1.01 (0.40–2.52)
Overdominant
AA + GG
47 (45.19%
124 (60.20%)
1.00
1.00
AG
57 (54.81%)
82 (39.80%)
0.01
1.83 (1.14–2.95)
0.04
1.68 (1.02–2.77)
Haplotypes
CA
58.21%
63.70%
1.00
1.00
CG
23.52%
18.58%
0.16
1.41 (0.88–2.25)
0.2
1.39 (0.84–2.29)
AG
11.57%
10.06%
0.44
1.29 (0.68–2.44)
0.46
1.29 (0.66–2.53)
AA
6.70%
7.66%
0.95
0.97 (0.41–2.31)
0.76
0.87 (0.35–2.18)
Allele and genotype frequencies are presented as absolute numbers with percentages in parentheses. OR: odds ratio; CI: confidence interval. Univariate analysis is based on χ2 test. Multivariate analysis is adjusted by gender, age, and APOE-ε4 positivity. is considered as significant.
