Mast Cells Exert Anti-Inflammatory Effects in an IL10^−/− Model of Spontaneous Colitis

Figure 5

Mast cell deficiency in colitis results in dysregulation of many cytokines and chemokines. (a) Scatter plot representation of average fold change of 84 different cytokine and chemokine genes in IL10^−/− compared to DKO mice from RNA extracted from whole colon. Dots above the lines are higher in DKO than in IL10^−/− mice, and dots below the line are greater than 2-fold decreased in DKO compared to IL10^−/− mice. (b) Reconstitution of DKO mice with BMMCs ameliorates the alteration of cytokines. Represents averaged fold change values in mice per group.

(a)

(b)