Predictive Role of Serum Cytokine Profiles in Acute Kidney Injury after Living Donor Liver Transplantation
Table 1
Comparison of perioperative findings between patients with and without acute kidney injury after living donor liver transplantation.
n
Non-AKI group
AKI group
p
173
53
Preoperative recipient factor
Age (years)
53 (48–59)
53 (49–60)
0.728
Gender (male)
115 (66.5%)
44 (83.0%)
0.021
Body mass index (kg/m2)
24.1 (21.8–25.9)
24.4 (22.2–28.1)
0.222
Etiology
0.173
Alcohol
32 (18.5%)
12 (22.6%)
Hepatitis B
102 (59.0%)
36 (67.9%)
Hepatitis C
11 (6.4%)
1 (1.9%)
Autoimmune
5 (2.9%)
0 (0.0%)
Drug & toxin
11 (6.4%)
4 (7.5%)
Cryptogenic findings
12 (6.9%)
0 (0.0%)
MELD score (points)
14 (9–22)
15 (10–25)
0.275
Complications of hepatic decompression
Severe encephalopathy
12 (6.9%)
2 (3.8%)
0.528
Varix
44 (25.4%)
13 (24.5%)
0.878
Ascites (≥1 L)
67 (38.7%)
26 (49.1%)
0.181
Laboratory value
Hematocrit (%)
30.1 (25.2–36.3)
28.4 (25.3–32.2)
0.146
Sodium (mEq/L)
139.0 (135.0–142.0)
139.0 (136.0–141.0)
0.763
Creatinine (mg/dL)
0.8 (0.7–1.0)
0.7 (0.6–0.9)
0.015
MDRD GFR (mL/min/1.73 m2)
96 (72–128)
117 (86–158)
0.015
C-reactive protein (mg/dL)
0.3 (0.1–0.9)
0.7 (0.2–1.7)
0.004
Platelet (×109/L)
67.0 (47.0–119.5)
52.0 (38.5–77.0)
0.006
Total bilirubin (mg/dL)
2.0 (0.8–6.7)
2.5 (1.1–8.3)
0.354
International normalized ratio
1.4 (1.2–1.8)
1.6 (1.3–1.9)
0.093
Intraoperative recipient factor
Total operation duration (min)
525 (455–574)
495 (465–560)
0.522
Severe postreperfusion syndrome
28 (16.2%)
19 (35.8%)
0.002
Blood product transfusion (unit)
Packed red blood cell
6 (3–11)
8 (5–12)
0.057
Fresh frozen plasma
6 (4–10)
8 (5–13)
0.006
Platelet concentrate
0 (0–6)
5 (0–10)
0.035
Cryoprecipitate
0 (0–0)
0 (0–0)
0.090
Hourly fluid administration (mL/kg/h)
10.1 (7.9–12.6)
8.2 (6.4–13.1)
0.174
Hourly urine output (mL/kg/h)
1.4 (0.8–2.2)
1.1 (0.7–1.9)
0.085
Furosemide administration (mg)
5 (0–20)
10 (0–33)
0.094
Donor-graft factor
Age (years)
31 (24–41)
36 (28–48)
0.027
Gender (male)
76 (43.9%)
21 (39.6%)
0.524
Body mass index (kg/m2)
23.0 (21.1–25.4)
23.0 (21.4–25.9)
0.587
Graft volume to standard liver volume ratio at time of transplantation (%)
55.4 (48.5–65.4)
53.5 (47.3–64.4)
0.505
Steatosis percentage (%)
3.0 (0.0–5.0)
4.0 (0.0–5.0)
0.958
Total ischemic time (min)
98 (71–124)
102 (70–158)
0.366
AKI: acute kidney injury; MELD: model for end-stage liver disease; MDRD: the Modification of Diet in Renal Disease Study equation; GFR: glomerular filtration rate. Severe encephalopathy: West-Haven criteria III or IV. Values are expressed as numbers (portions) and median (interquartile).
