Lactate as a Potential Biomarker of Sepsis in a Rat Cecal Ligation and Puncture Model
(a) Receiver operating characteristic (ROC) curve showed the best cutoff value of Lac to discriminate septic rats from nonseptic rats after CLP insult was 1.64 mmol/L (Youden score of 0.722). (b) The 7-day survival analysis (/each group). (c) The 7-day MSS. The group size reported for MSS data varied over time, reflecting the mortality rate ( at day 1, at other time points). versus L group. The serum levels of PCT (d) and HMGB1 (e) were significantly higher in animals in the M group compared with the L group, versus baseline, versus L group.