Restoring Inflammatory Mediator Balance after Sofosbuvir-Induced Viral Clearance in Patients with Chronic Hepatitis C
Table 2
Cytokine range in serum chronic hepatitis C patients compared to HCV noninfected controls.
Chronic hepatitis C
Control group
value
Chemokines
CCL-3
2.8 (0.9–16.6)
1.3 (0.6–1.6)
NS
CCL-4
50.9 (34.5–89.2)
24.9 (18.5–28.8)
0.001
CCL-5
3186 (2032–4881)
2625 (2025–3370)
NS
CCL-11
722.7 (597.7–944.5)
788.9 (261.1–1235.0)
NS
CXCL-10
29,385 (18,159–44,260)
9120 (4075–10,196)
0.0001
Pro-inflammatory
IFN-γ
98.4 (53.4–324.8)
33.3 (14.5–51.8)
0.002
IL-1β
0.3 (0.1–0.5)
0.2 (0.03–0.2)
NS
Anti-inflammatory
IL-10
4.0 (2.7–5.6)
4.6 (2.4–41.2)
NS
IL-1ra
246.3 (98.0–1102.0)
307.5 (46.0–603.1)
NS
TGF-β
2781 (1856–3302)
3821 (3239–4098)
0.004
Growth factors
FGFb
423.9 (167.7–976.3)
314.9 (115.4–435.9)
NS
PDGF-B
7932 (2183–78,666)
51,254 (28,252–71,775)
NS
VEGF
65.4 (33.3–149.3)
73.5 (31.4–4269.0)
NS
Others
PAI-1
15,325 (8890–21,330)
5038 (3276–13,210)
0.008
suPAR
2478 (1772–3320)
1575 (1283–1878)
0.023
Data are presented as median (interquartile range). NS: nonsignificant. HCV-noninfected individuals who presented detectable levels of CCL-2, CXCL-8, and IL-15 were not enough for analysis. Statistical significance was assessed by Mann–Whitney or unpaired -test (). The bold numbers indicate values < 0.05.
