The Effects of MicroRNAs on Key Signalling Pathways and Epigenetic Modification in Fibroblast-Like Synoviocytes of Rheumatoid Arthritis

Table 1

The summary of individual miRNAs in RA FLS.

miRNA	Targets	RA	Pathways	Reference
miR-26b	GSK-3P	Repression	Wnt	[19]
miR-375	FZD8	Repression	Wnt	[20]
miR-663	APC	Promotion	Wnt	[21]
miR-323	BTRC	Promotion	Wnt	[22]
miR-152	DNMT1	Repression	Wnt	[23]
miR-146	IRAKI, TRAF6	Promotion	NF-κB	[26, 28]
miR-155	RIP1JKK	Promotion	NF-κB	[27]
miR-27a	FSTL1	Repression	NF-κB	[28]
miR-21	NF-κB nuclear translocation	Promotion	NF-κB	[29]
miR-23b	TAB2, TAB3, and IKK-a	Repression	NF-κB	[22]
miR-lOa	IRAK4, TAK1 and BTRC	Promotion	NF-κB	[32]
miR-203	Not identified	Promotion	NF-κB	[33]
miR-17	TRAF2	Repression	NF-κB	[34]
miR-18a	TNFAIP-3	Promotion	NF-κB	[35]
miR-19	Rnfll, Kdm2a, Tnfaip3, Zbtbl6	Promotion	NF-κB	[36]
miR-29	DNMT3a	Repression	DNA methylation	[39]
miR-152	DNMT1	Repression	DNA methylation	[23]
miR-124/203/34a/34a	Regulated by DNA methylation	Promotion	DNA methylation	[33, 41, 42]