Mediators of Inflammation / 2018 / Article / Fig 2

Research Article

Neostigmine Attenuates Proinflammatory Cytokine Expression in Preoptic Area but Not Choroid Plexus during Lipopolysaccharide-Induced Systemic Inflammation

Figure 2

Effect of lipopolysaccharide (LPS; 400 ng/kg; iv.) and acetylcholinesterase inhibitors: donepezil (2.5 mg/animal; iv.) and neostigmine (0.5 mg/animal; iv.) injections on the level of proinflammatory cytokines—interleukin- (IL-) 1β (a), IL-6 (b), and tumor necrosis factor (TNF) α (c) in the preoptic area of the hypothalamus. The data are presented as the mean value ± SEM. Different capital letters indicate significant differences according to a two-way ANOVA followed by Fisher’s post hoc test. Statistical significance was defined at .

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