Graft versus Host Disease: From Basic Pathogenic Principles to DNA Damage Response and Cellular Senescence

<div>ATM kinase has a crucial role in the initiation of SASP in the DNA damage response and is required for the secretion of the two major inflammatory cytokines, for example, IL-6 and IL-8. Persistent DNA damage stimulates NF-<i>κ</i>B signaling, which consequently regulates the expression of various SASP-related genes.</div>

Mediators of Inflammation

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Figure 2

Figure 2: Graft versus Host Disease: From Basic Pathogenic Principles to DNA Damage Response and Cellular Senescence 