Mediators of Inflammation

Research Article

Plasma Asprosin Concentrations Are Increased in Individuals with Glucose Dysregulation and Correlated with Insulin Resistance and First-Phase Insulin Secretion

Table 1

Clinical and laboratory characteristics of the study subjects.


	NGR	IGR	nT2DM

Sex (M/F)	52 (17/35)	40 (15/25)	51 (27/24)
Age (year)	54.73 ± 11.90	54.00 ± 9.62	53.73 ± 10.06
BMI (kg/m²)	22.76 ± 3.61	23.86 ± 3.08	24.73 ± 3.55
Wc (cm)	81.08 ± 9.05	88.18 ± 6.48	87.71 ± 9.36
WHR	0.86 ± 0.06	0.87 ± 0.07	0.90 ± 0.06
SBP (mmHg)	120.98 ± 14.04	125.03 ± 12.76	126.75 ± 13.71
DBP (mmHg)	75.42 ± 9.36	75.75 ± 9.14	79.10 ± 11.51
FPG (mmol/L)	5.19 ± 0.34	6.68 ± 0.25	8.27 ± 1.92
2hPG (mmol/L)	4.70 ± 0.60	6.90 ± 1.17	11.79 ± 3.50
HbA1c (%/mmol/mol)	5.55 ± 0.32/37	6.01 ± 0.41/42	7.78 ± 1.89/62
FINS (mU/L)	5.92 ± 3.59	7.18 ± 3.79	8.25 ± 4.14
HOMA-IR	1.38 ± 0.88	2.14 ± 1.16	3.02 ± 1.64
HOMA-β	71.03 ± 41.79	44.83 ± 22.80	38.92 ± 22.97
AUC	498.95 ± 481.04	165.86 ± 109.59	100.96 ± 113.99
AIR	62.89 ± 61.81	17.17 ± 11.69	10.93 ± 13.07
GDI	1.61 ± 0.45	1.30 ± 0.31	0.97 ± 0.26
TC (mmol/L)	4.41 ± 0.98	4.73 ± 1.02	4.79 ± 1.08
TG (mmol/L)	1.20 ± 0.50	1.98 ± 1.40	1.90 ± 1.06
HDL-C (mmol/L)	1.52 ± 0.52	1.32 ± 0.31	1.27 ± 0.31
LDL-C (mmol/L)	2.45 ± 0.95	2.84 ± 0.76	2.83 ± 1.00
hsCRP (mg/L)	1.37 ± 3.36	0.94 ± 0.78	2.31 ± 1.01
Asprosin (ng/mL)	16.22 ± 9.27	82.40 ± 91.06	73.25 ± 91.69

Data are presented as means ± SD. NGR: normal glucose regulation; IGR: impaired glucose regulation; nT2DM: newly diagnosed type 2 diabetes; BMI: body mass index; Wc: waist circumference; WHR: waist hip ratio; SBP: systolic blood pressure; DBP: diastolic blood pressure; FPG: fasting plasma glucose; 2hPG: 2 h postchallenge plasma glucose; FINS: fasting serum insulin; HOMA-IR: homeostasis model assessment for insulin resistance; HOMA-β: homeostasis model assessment for beta-cell function; AUC: area under the curve of the first-phase (0–10 min) insulin secretion; AIR: acute insulin response; GDI: glucose disposition index; TC: total cholesterol; TG: triglyceride; HDL-C: high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; hsCRP: hypersensitive C-reactive protein. compared with NGT; compared with NGT; compared with pre-DM; compared with pre-DM.