Chronic Inflammation as a Link between Periodontitis and Carcinogenesis

<div>Host response mechanisms of cellular transformation induced by periodontal bacteria. Inhibition of apoptosis, epithelial-mesenchymal transition (EMT), invasion and migration, metastasis, and proliferation are triggered through the activation of prooncogenic pathways by <i>P. gingivalis</i> (red arrows), <i>T. denticola</i> (purple arrows), <i>F. nucleatum</i> (yellow arrow), and <i>P. gingivalis</i>+<i>F. nucleatum</i> coinfection (orange arrows).</div>

Mediators of Inflammation

fig2

Figure 2

Figure 2: Chronic Inflammation as a Link between Periodontitis and Carcinogenesis 