Macrophage Migration Inhibitory Factor Promotes the Interaction between the Tumor, Macrophages, and T Cells to Regulate the Progression of Chemically Induced Colitis-Associated Colorectal Cancer

Figure 1

Chemical colitis-associated cancer increases serum MIF levels. (a) Both WT and MIF^-/- female BALB/c mice were injected via intraperitoneal injection with AOM; then, 3 cycles of 2% DSS were administered in drinking water, each followed by 14 days of water free of DSS. (b) Weight gain was supervised during cancer development. MIF concentrations (c) in blood serum over time (after each DSS cycle at 12, 33, 54, and 68 days) and (d) in colonic tissue after 68 days were measured by ELISA. Data are representative of three independent experiments and are plotted as the means (±SEM), mice per group; , , and . MIF: macrophage migration inhibitory factor; CRC: colorectal cancer; AOM: azoxymethane; DSS: dextran sodium sulfate; d.p.i: days post induction.

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