Mediators of Inflammation / 2019 / Article / Tab 2

Review Article

Systematic Review with Meta-Analysis: Fecal Calprotectin as a Surrogate Marker for Predicting Relapse in Adults with Ulcerative Colitis

Table 2

Assessment of diagnostic accuracy and heterogeneity in subgroup analysis.

CategoryNumber of studiesSensitivitySpecificityPLRNLRDOR (%) of DOR

Total140.75 (0.70–0.79)0.77 (0.74–0.80)3.45 (2.31–5.14)0.37 (0.28–0.49)10.54 (6.16–18.02)57.0
Number of patients
 ≥8060.78 (0.72-0.83)0.75 (0.71-0.79)3.39 (1.77-6.51)0.32 (0.23-0.43)11.18 (4.96-25.19)72.5
 <8080.68 (0.59-0.76)0.81 (0.76-0.85)3.38 (2.10-5.43)0.44 (0.30-0.63)9.60 (4.57-20.15)39.5
Mean age
 ≥40100.73 (0.67-0.79)0.75 (0.71-0.79)3.34 (2.00-5.58)0.40 (0.30-0.53)9.61 (4.75-19.47)62.3
 <4040.77 (0.68-0.85)0.81 (0.76-0.86)3.92 (2.96-5.20)0.30 (0.15-0.62)13.44 (6.31-28.60)34.9
Male ratio
 ≥50%100.75 (0.70-0.80)0.75 (0.72-0.79)3.71 (1.97-5.10)0.37 (0.26-0.52)9.98 (5.16-19.32)67.7
 <50%40.70 (0.53-0.84)0.84 (0.78-0.89)4.31 (2.38-7.80)0.39 (0.24-0.62)12.49 (5.31-29.37)0
FC assay
 Bühlmann40.75 (0.65-0.83)0.87 (0.80-0.91)5.07 (3.32-7.75)0.34 (0.16-0.72)15.35 (5.28-44.61)44.8
 Not Bühlmann100.74 (0.68-0.80)0.75 (0.71-0.78)3.05 (1.98-4.69)0.38 (0.28-0.52)9.34 (5.06-17.24)58.0
Cutoff value
 ≥150 μg/g90.71 (0.65-0.78)0.86 (0.82-0.89)4.42 (3.00-6.53)0.38 (0.26-0.55)14.06 (7.17-27.58)49.9
 <150 μg/g50.79 (0.71-0.85)0.64 (0.58-0.69)2.19 (1.32-3.64)0.36 (0.25-0.50)6.72 (2.95-15.47)59.8
Follow-up time
 ≥1 y120.73 (0.68-0.78)0.81 (0.78-0.84)3.66 (2.52-5.31)0.38 (0.28-0.50)11.18 (6.32-19.78)59.8
 <1 y20.89 (0.72-0.98)0.44 (0.33-0.57)2.20 (0.66-7.28)0.31 (0.11-0.88)7.01 (0.92-53.25)41.0

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